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1

Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the sponge Phorbas sp.

Pattenden, Gerald, Gonz�lez, Miguel A., Little, Paul B., Millan, David S., Plowright, Alleyn T., Tornos, James A., Ye, Tao

Journal:

Organic & Biomolecular Chemistry

Year:

2003

Language:

english

File:

PDF, 713 KB

english, 2003

2

CH-Functionalization - Prediction of Selectivity in Iridium(I) Catalyzed Hydrogen Isotope Exchange Competition Reactions

Valero, Mégane, Kruissink, Thomas, Blass, Jennifer, Weck, Remo, Güssregen, Stefan, Plowright, Alleyn T., Derdau, Volker

Journal:

Angewandte Chemie International Edition

Year:

2020

Language:

english

File:

PDF, 1.91 MB

english, 2020

3

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) ||

Plowright, Alleyn T

Year:

2019

File:

PDF, 10.20 MB

2019

4

Rethinking drug design in the artificial intelligence era

Schneider, Petra, Walters, W. Patrick, Plowright, Alleyn T., Sieroka, Norman, Listgarten, Jennifer, Goodnow, Robert A., Fisher, Jasmin, Jansen, Johanna M., Duca, José S., Rush, Thomas S., Zentgraf, Ma

Journal:

Nature Reviews Drug Discovery

Year:

2019

File:

PDF, 1.44 MB

2019

5

[Annual Reports in Medicinal Chemistry] || Phenotypic Screening

Plowright, Alleyn T.

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

6

New Modalities for Challenging Targets in Drug Discovery

Waldmann, Herbert, Valeur, Eric, Guéret, Stéphanie M., Adihou, Hélène, Gopalakrishnan, Ranganath, Lemurell, Malin, Grossmann, Tom N., Plowright, Alleyn T.

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 4.57 MB

english, 2017

7

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Affinity‐Based Chemoproteomics for Target Identification

Plowright, Alleyn T

Year:

2019

File:

PDF, 2.05 MB

2019

8

Synthetic studies towards phorboxazole A. A convergent synthesis of the C31C46 polyene oxane-hemiacetal side chain

Gerald Pattenden, Alleyn T Plowright, James A Tornos, Tao Ye

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 230 KB

english, 1998

9

Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle

Alleyn T. Plowright, Craig Johnstone, Jan Kihlberg, Jonas Pettersson, Graeme Robb, Richard A. Thompson

Journal:

Drug Discovery Today

Year:

2012

Language:

english

File:

PDF, 334 KB

english, 2012

10

Discovery of AZD6642, an Inhibitor of 5-Lipoxygenase Activating Protein (FLAP) for the Treatment of Inflammatory Diseases

Lemurell, Malin, Ulander, Johan, Winiwarter, Susanne, Dahlén, Anders, Davidsson, Öjvind, Emtenäs, Hans, Broddefalk, Johan, Swanson, Marianne, Hovdal, Daniel, Plowright, Alleyn T., Pettersen, Anna, Ryd

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

11

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Index

Plowright, Alleyn T

Year:

2019

Language:

english

File:

PDF, 90 KB

english, 2019

12

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery

Plowright, Alleyn T

Year:

2019

File:

PDF, 792 KB

2019

13

CâH FunctionalizationâPrediction of Selectivity in Iridium(I)âCatalyzed Hydrogen Isotope Exchange Competition Reactions

Valero, MÃ©gane, Kruissink, Thomas, Blass, Jennifer, Weck, Remo, GÃ¼ssregen, Stefan, Plowright, Alleyn T., Derdau, Volker

Journal:

Angewandte Chemie

Year:

2020

Language:

english

File:

PDF, 1.54 MB

english, 2020

14

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

Bao, Xiaoping, Lian, Xiaojun, Hacker, Timothy A., Schmuck, Eric G., Qian, Tongcheng, Bhute, Vijesh J., Han, Tianxiao, Shi, Mengxuan, Drowley, Lauren, Plowright, Alleyn T., Wang, Qing-Dong, Goumans, Ma

Journal:

Nature Biomedical Engineering

Year:

2016

Language:

english

File:

PDF, 6.45 MB

english, 2016

15

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Label‐Free Techniques for Target Discovery and Validation

Plowright, Alleyn T

Year:

2019

File:

PDF, 554 KB

2019

16

Joining Forces: The Chemical Biology–Medicinal Chemistry Continuum

Plowright, Alleyn T., Ottmann, Christian, Arkin, Michelle, Auberson, Yves P., Timmerman, Henk, Waldmann, Herbert

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

17

CRISPR-KO screen identifies Dmap1 as a regulator of chemically-induced reprogramming and differentiation of cardiac progenitors

Yu, Jason S. L., Palano, Giorgia, Lim, Cindy, Moggio, Aldo, Drowley, Lauren, Plowright, Alleyn T., Bohlooly-Y, Mohammad, Rosen, Barry S., Hansson, Emil M., Wang, Qing-Dong, Yusa, Kosuke

Journal:

Year:

2019

Language:

english

File:

PDF, 2.02 MB

english, 2019

18

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Reverse Translation to Support Efficient Drug Target Selection and Stratified Medicine

Plowright, Alleyn T

Year:

2019

File:

PDF, 400 KB

2019

19

Medicinal Chemistry Approaches to Heart Regeneration

Schade, Dennis, Plowright, Alleyn T.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.07 MB

english, 2015

20

ChemInform Abstract: Heart Regeneration: Opportunities and Challenges for Drug Discovery with Novel Chemical and Therapeutic Methods or Agents

Plowright, Alleyn T., Engkvist, Ola, Gill, Adrian, Knerr, Laurent, Wang, Qing-Dong

Journal:

Year:

2014

File:

PDF, 12 KB

2014

21

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Elucidating Target Biology and Drug Mechanism of Action Across Human Cell‐Based Model Systems

Plowright, Alleyn T

Year:

2019

File:

PDF, 807 KB

2019

22

High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets

Woo, Laura A., Tkachenko, Svyatoslav, Ding, Mei, Plowright, Alleyn T., Engkvist, Ola, Andersson, Henrik, Drowley, Lauren, Barrett, Ian, Firth, Mike, Akerblad, Peter, Wolf, Matthew J., Bekiranov, Stefa

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2019

Language:

english

File:

PDF, 1.87 MB

english, 2019

23

Towards second generation cardiomyogenic and anti-cardiofibrotic 1,4-dihydropyridine-class of TGFβ inhibitors

Laengle, Daniel, Werner, Tessa R, Wesseler, Fabian, Reckzeh, Elena S, Schaumann, Niklas, Drowley, Lauren, Polla, Magnus, Plowright, Alleyn T, Hirt, Marc N, Eschenhagen, Thomas, Schade, Dennis

Journal:

Year:

2019

Language:

english

File:

PDF, 2.38 MB

english, 2019

24

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Cell Biology Methods in Target Validation

Plowright, Alleyn T

Year:

2019

File:

PDF, 954 KB

2019

25

ChemInform Abstract: Synthesis and Evaluation of Bishydroquinone Derivatives of (-)-Saframycin A: Identification of a Versatile Molecular Template Imparting Potent Antiproliferative Activity.

Andrew G. Myers, Alleyn T. Plowright

Journal:

Year:

2001

File:

PDF, 29 KB

2001

26

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Genetic Manipulation/Modulation for Target Discovery and Validation

Plowright, Alleyn T

Year:

2019

File:

PDF, 576 KB

2019

27

Automated De-Novo Design in Medicinal Chemistry: Which Types of Chemistry Does a Generative Neural Network Learn?

Grebner, Christoph, Matter, Hans, Plowright, Alleyn T., Hessler, Gerhard

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.25 MB

2020

28

Skeletal diversity construction via a branching synthetic strategy

Wyatt, Emma E., Fergus, Suzanne, Galloway, Warren R. J. D., Bender, Andreas, Fox, David J., Plowright, Alleyn T., Jessiman, Alan S., Welch, Martin, Spring, David R.

Journal:

Chemical Communications

Year:

2006

Language:

english

File:

PDF, 389 KB

english, 2006

29

Oxadiazoles in Medicinal Chemistry

Boström, Jonas, Hogner, Anders, Llinàs, Antonio, Wellner, Eric, Plowright, Alleyn T.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 4.15 MB

english, 2012

30

Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein–Protein Interaction

Cheng, Leifeng, Pettersen, Daniel, Ohlsson, Bengt, Schell, Peter, Karle, Michael, Evertsson, Emma, Pahlén, Sara, Jonforsen, Maria, Plowright, Alleyn T., Boström, Jonas, Fex, Tomas, Thelin, Anders, Hil

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.62 MB

english, 2014

31

Emerging modes-of-action in Drug Discovery

Valeur, Eric, Narjes, Frank, Ottmann, Christian, Plowright, Alleyn

Journal:

Year:

2019

Language:

english

File:

PDF, 2.86 MB

english, 2019

32

Total Synthesis of (+)-Phorboxazole A, a Potent Cytostatic Agent from the Sponge Phorbas sp.

Gerald Pattenden, Miguel A. Gonzalez, Paul B. Little, David S. Millan, Alleyn T. Plowright, James A. Tornos, Tao Ye

Journal:

Year:

2004

File:

PDF, 69 KB

2004

33

Synthesis and Evaluation of Bishydroquinone Derivatives of (−)-Saframycin A: Identification of a Versatile Molecular Template Imparting Potent Antiproliferative Activity

Myers, Andrew G., Plowright, Alleyn T.

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 41 KB

english, 2001

34

Heart Regeneration: Opportunities and Challenges for Drug Discovery with Novel Chemical and Therapeutic Methods or Agents

Plowright, Alleyn T., Engkvist, Ola, Gill, Adrian, Knerr, Laurent, Wang, Qing-Dong

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 2.72 MB

english, 2014

35

What is the most important approach in current drug discovery: doing the right things or doing things right?

Thomas Elebring, Adrian Gill, Alleyn T. Plowright

Journal:

Drug Discovery Today

Year:

2012

Language:

english

File:

PDF, 299 KB

english, 2012

36

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Front Matter

Plowright, Alleyn T

Year:

2019

File:

PDF, 135 KB

2019

37

Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells

Ding, Mei, Andersson, Henrik, Martinsson, Sofia, Sabirsh, Alan, Jonebring, Anna, Wang, Qing-Dong, Plowright, Alleyn T., Drowley, Lauren

Journal:

Scientific Reports

Year:

2020

File:

PDF, 1.74 MB

2020

38

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Index

Plowright, Alleyn T

Year:

2019

File:

PDF, 90 KB

2019

39

Transcriptional Response Pathways in a Yeast Strain Sensitive to Saframycin A and a More Potent Analog: Evidence for a Common Basis of Activity

Alleyn T. Plowright, Scott E. Schaus, Andrew G. Myers

Journal:

Chemistry & Biology

Year:

2002

Language:

english

File:

PDF, 174 KB

english, 2002

40

Comparative transcriptomic analysis identifies genes differentially expressed in human epicardial progenitors and hiPSC-derived cardiac progenitors

Synnergren, Jane, Drowley, Lauren, Plowright, Alleyn T., Brolén, Gabriella, Goumans, Marie-José, Gittenberger-de Groot, Adriana C., Sartipy, Peter, Wang, Qing-Dong

Journal:

Physiological Genomics

Year:

2016

Language:

english

File:

PDF, 3.86 MB

english, 2016

41

Herzregeneration: Chancen und Aufgaben für die Wirkstoff-Forschung mit neuartigen chemischen und therapeutischen Methoden oder Agentien

Plowright, Alleyn T., Engkvist, Ola, Gill, Adrian, Knerr, Laurent, Wang, Qing-Dong

Journal:

Angewandte Chemie

Year:

2014

Language:

german

File:

PDF, 2.45 MB

german, 2014

42

Directing evolution: the next revolution in drug discovery?

Davis, Andrew M., Plowright, Alleyn T., Valeur, Eric

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 958 KB

english, 2017

43

A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions

David Buttar, Nicola Colclough, Stefan Gerhardt, Philip A. MacFaul, Scott D. Phillips, Alleyn Plowright, Paul Whittamore, Kin Tam, Klaus Maskos, Stefan Steinbacher, Holger Steuber

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.46 MB

english, 2010

44

Synthetic studies towards phorboxazole A. Stereoselective synthesis of the C3–C19 bis-oxane oxazole portion of the phorboxazole macrolide

Gerald Pattenden, Alleyn T Plowright

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

45

Cardiovascular and Metabolic Disease: Scientific Discoveries and New Therapies. Edited by Philip Peplow, James Adams, Tim Young

Plowright, Alleyn T.

Journal:

Year:

2015

Language:

english

File:

PDF, 236 KB

english, 2015

46

New Modalities for Challenging Targets in Drug Discovery

Waldmann, Herbert, Valeur, Eric, Guéret, Stéphanie M., Adihou, Hélène, Gopalakrishnan, Ranganath, Lemurell, Malin, Grossmann, Tom N., Plowright, Alleyn T.

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 4.57 MB

english, 2017

47

Front Cover: Toward Second‐Generation Cardiomyogenic and Anti‐cardiofibrotic 1,4‐Dihydropyridine‐Class TGFβ Inhibitors (ChemMedChem 8/2019)

Längle, Daniel, Werner, Tessa R., Wesseler, Fabian, Reckzeh, Elena, Schaumann, Niklas, Drowley, Lauren, Polla, Magnus, Plowright, Alleyn T., Hirt, Marc N., Eschenhagen, Thomas, Schade, Dennis

Journal:

Year:

2019

File:

PDF, 644 KB

2019

48

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Chemical Strategies for Evaluating New Drug Targets

Plowright, Alleyn T

Year:

2019

File:

PDF, 415 KB

2019

49

[Methods and Principles in Medicinal Chemistry] Target Discovery and Validation (Methods and Strategies for Drug Discovery) || Computational Approaches for Target Inference

Plowright, Alleyn T

Year:

2019

File:

PDF, 1.07 MB

2019

50

Cyclic Peptide Production Using a Macrocyclase with Enhanced Substrate Promiscuity and Relaxed Recognition Determinants

Alexandru-Crivac, Cristina Nicoleta, Umeobika, Ugochukwu, Leikoski, Niina, jokela, jouni, Rickaby, Kirstie A, Grilo, André M, Sjö, Peter, Plowright, Alleyn, Idress, Mohannad, Siebs, Eike, Nneoyiegbe

Journal:

Chemical Communications

Year:

2017

Language:

english

File:

PDF, 884 KB

english, 2017

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